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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) (NCT04793958)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD (NCT06267560)
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents (NCT06120491)
A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease (NCT06522997)
A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products (NCT06979804)
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03) (NCT06797635)
Denosumab for Type 1 Diabetes (NCT06524960)
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004) (NCT06136650)
A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT [PIVOT-006] (NCT06111235)
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (NCT06319820)
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy (NCT05206513)
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy (NCT00680264)
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG) (NCT06211764)
Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy (NCT05834738)
Horizon Adaptive Platform Trial Evaluating Therapies in RRMM (NCT06171685)
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC [CORE-008] (NCT06567743)
DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC (NCT06364917)
Select Patient
Brian Jones
Amanda Smith
Joseph Jones
Margaret Davis
FHIR Patient JSON
{ "patient": {"resourceType":"Patient","id":"NCT04793958-4","identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Jones","given":["Brian"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"brian.jones@example.com","use":"home"}],"gender":"male","birthDate":"1970-05-15","address":[{"use":"home","line":["123 Main St"],"city":"Springfield","state":"IL","postalCode":"62701","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]}, "fhirResources": [{"resourceType":"Condition","id":"NCT04793958-4-0","verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"363406005","display":"Malignant neoplasm of colon"}]},"subject":{"reference":"Patient/NCT04793958-4"}},{"resourceType":"Observation","id":"NCT04793958-4-1","code":{"coding":[{"system":"http://loinc.org","code":"33762-4","display":"KRAS gene mutation analysis"}]},"subject":{"reference":"Patient/NCT04793958-4"},"valueString":"KRAS G12C mutation"},{"resourceType":"MedicationStatement","id":"NCT04793958-4-2","status":"active","subject":{"reference":"Patient/NCT04793958-4"}},{"resourceType":"Procedure","id":"NCT04793958-4-3","code":{"coding":[{"system":"http://snomed.info/sct","code":"367336001","display":"Chemotherapy"}]},"subject":{"reference":"Patient/NCT04793958-4"}} ], "patientNote": "Patient is a 53-year-old male with a history of colorectal carcinoma, confirmed to have a KRAS G12C mutation. He has previously undergone a fluoropyrimidine-based chemotherapy regimen with oxaliplatin. Recent imaging shows progression of the disease, indicating a need for second-line treatment. Patient denies any significant neurological symptoms, and there is no evidence of active brain metastasis. He has not received any prior treatment targeting the KRAS G12C mutation or anti-EGFR antibodies. Patient reports occasional abdominal discomfort but denies any severe pain or changes in bowel habits. He is currently managing well with his prescribed medications and maintains a good performance status. Blood work shows stable liver and kidney function. Patient is married and lives with his spouse, who is supportive and involved in his care. He is fluent in English and prefers to communicate in this language during medical consultations.", "grade": "Disqualified" }
Patient Note
Patient is a 53-year-old male with a history of colorectal carcinoma, confirmed to have a KRAS G12C mutation. He has previously undergone a fluoropyrimidine-based chemotherapy regimen with oxaliplatin. Recent imaging shows progression of the disease, indicating a need for second-line treatment. Patient denies any significant neurological symptoms, and there is no evidence of active brain metastasis. He has not received any prior treatment targeting the KRAS G12C mutation or anti-EGFR antibodies. Patient reports occasional abdominal discomfort but denies any severe pain or changes in bowel habits. He is currently managing well with his prescribed medications and maintains a good performance status. Blood work shows stable liver and kidney function. Patient is married and lives with his spouse, who is supportive and involved in his care. He is fluent in English and prefers to communicate in this language during medical consultations.
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